The Ghana Integrated Logistics Management Information System (GhiLMIS) is designed to support supply chain decision making, inventory visibility and operations throughout the entire supply chain. It is currently implemented in over 1500 facilities. The system implementation is funded by the Global Fund and its successful implem9entation is based on a patient centric driven approach, ensuring quality data production and use, while improving and optimizing operational performance and reducing overall supply chain costs.  The shifting of the paradigm, from the mundane reporting driven systems, and focusing on usage of data for informed decisions, led to significant impacts within the shortest period. This transformational approach enabled full utilization of the system in meeting and addressing covid-19 supply chain needs.  It facilitated the adoption of an agile approach in addressing the disruptions caused by the pandemic and provided critical data that facilitated effective decision making and responsiveness.